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5 Best IV Therapy Franchises to Invest in 2025

Nov 12, 2024

Faizan and Adila Kahn photo on a grey background and white text and purple button that says GLO30

The IV therapy industry is exploding, and for good reason. Consumers are actively seeking wellness and preventive health services that fit their busy, health-conscious lifestyles. With the market expected to grow to $13.4 billion by 2028, IV therapy franchises offer an unprecedented opportunity for investors to capitalize on a sector with strong, consistent growth.

Why Invest in an IV Therapy Franchise?

  1. Soaring Demand: People are searching for convenient, effective wellness solutions—and IV therapy delivers.
  2. Proven Business Models: Franchises offer a tried-and-tested path to success with established frameworks.
  3. Scalability: From recurring revenue streams to expansion opportunities, IV therapy franchises are built for growth.

Below are the five best IV therapy franchises that are leading the industry. Each stands out for its unique approach, solid market presence, and exceptional support for franchisees, making them top choices for anyone looking to get in on this booming industry.

1. OnusThe First Longevity Franchise of Its Kind

Onus has redefined vitality and longevity focused care with not only IV therapy, but also hormone replacement therapy (BHRT), NAD+, a premium supplement line, and their revolutionary Longevity packs. Founded in 2015, Onus has served over 60,000 happy customers across 6 locations in Denver and is expanding nationwide through franchising with Fransmart.

What Sets Onus Apart

Onus is more than just an IV therapy service; it’s a lifestyle brand. They offer evidence-based, personalized treatments designed to optimize recovery, performance, and vitality, helping clients live their best days.

  • Unique Focus On Longevity: Onus prioritizes longevity, setting it apart from other IV therapy providers that focus solely on hydration or wellness. With advanced treatments like Bioidentical Hormone Replacement Therapy (BHRT), NAD+ infusions, in-location lab testing, and customized Longevity Packs, Onus addresses deeper health needs, supporting clients’ goals for sustained energy, mental clarity, and inspires everyone to live better, longer.
  • Over A Decade of Trailblazing Wellness: Onus was the first to bring IV Therapy to the Front Range and has been ahead of the curve ever since. For 10 years, they’ve changed how customers take control of their health, leading the way in the high-growth proactive wellness space.
  • Real Data, Real Results: Our data-driven approach is unmatched—advanced in-location lab testing and personalized longevity packs guide members to achieve real, measurable results.

Financial Overview

  • Initial Investment: $230,000-$515,000
  • Franchise Fee: $40,000
  • Royalties: 6%
  • Minimum Liquid Capital: $500,000
  • Minimum Net Worth: $1M (Investment partner

With Onus, you’re not just investing in an IV therapy franchise—you’re an early adopter in the lucrative longevity market that’s yet to be truly tapped into. With their strong support systems and innovative approach, this franchise is set to become a market leader.

2. Prime IV Hydration & Wellness — The Largest IV Therapy Franchise In The U.S.

Prime IV Hydration is a leading provider of IV therapy, offering a wide range of vitamin infusions designed to enhance wellness, energy, and overall health. Their clinics provide a luxurious spa-like atmosphere, aiming to make IV therapy both effective and relaxing. They were named the #1 IV Therapy franchise on the Entrepreneur Franchise 500.

  • Who Their Customer Is: Their primary customers include health-conscious individuals, athletes, busy professionals, and those seeking quick recovery from hangovers or illness.
  • How Many Locations They Have: 109 operating and 140 in development

Financial Overview

  • Initial Investment: $164,549 to $610,088
  • Franchise Fee: $49,000
  • Royalties: 7%
  • Minimum Liquid Capital: $100,000

3. Vida-Flo — An IV Therapy Franchise with An Uptick in Growth

Vida-Flo is a pioneer in the IV hydration therapy industry, offering medically supervised treatments designed to enhance overall wellness, athletic recovery, and beauty. The company promotes preventative healthcare by providing hydration and vitamin infusion services in a spa-like environment.

  • Who Their Customer Is: The typical customers are wellness enthusiasts, athletes, and professionals who need to quickly recover from travel, stress, or illness.
  • How Many Locations They Have: 6 corporate and 9 franchise locations

Financial Overview

  • Initial Investment: $209,350 to $349,500
  • Franchise Fee: $49,000
  • Royalties: 7%
  • Minimum Liquid Capital: $125,000
  • Minimum Net Worth: $500,000

4. Liquivida Lounge — An IV Therapy Franchise Expanding Into Wellness

Liquivida is a full-service wellness center specializing in IV therapy, medical aesthetics, and hormone replacement therapy. They offer a comprehensive approach to health, focusing on both physical appearance and internal well-being.

  • Who Their Customer Is: Their customer base includes individuals looking for anti-aging treatments, wellness enthusiasts, and those seeking to improve their overall health through IV nutrition and hormone therapy.
  • How Many Locations They Have: 21wellness centers, 9 IV drip centers, 5 integrated lounges

Financial Overview

  • Initial Investment: $645,375 to $929,600
  • Franchise Fee: ($75,000 to $82,100 must be paid to franchisor and affiliates)
  • Royalties: 6%
  • Minimum Liquid Capital: $50,000
  • Minimum Net Worth: $250,000

5. The DripBar — An IV Therapy Franchise Expanding In North America

The DripBar is carving out its niche by offering lifestyle drips that support overall wellness. Their quick, convenient services attract busy professionals and health-conscious individuals alike.

  • Who Their Customer Is: Their customer base are includes people looking to improve their cellular health and make a healthier choice for their lifestyle. Their model is limited to IV therapy only, but will be slightly expanding with Reviv.
  • How Many Locations They Have: 60 locations open and operating, and more than 600 additional locations in development.

Financial Overview

  • Initial Investment: $142,125 – $404,800
  • Franchise Fee: $55,000
  • Royalties: 7%
  • Minimum Liquid Capital: $100,000
  • Minimum Net Worth: $300,000

The Best Investment Opportunity: Onus

When it comes to the top choice for IV therapy franchises, Onus Longevity stands out for its innovative approach in a space . By focusing on performance, recovery, and vitality, Onus has carved out a unique position in the market.

Why Onus Longevity

    • Leader in Longevity: Onus goes beyond conventional wellness to deliver cutting-edge longevity solutions, appealing to a growing market focused on extended, high-quality living.
    • Adaptable Model Built To Scale: With hormone therapy (BHRT), NAD+ treatments, premium white-labeled supplements, and in-location lab testing, Onus stands miles above any other IV therapy franchise with a model built to keep franchisees ahead of the competition.
    • Nature-Inspired Lounges: Unlike the sterile feel of typical medical clinics or spa lounges, Onus creates inviting, nature-inspired spaces that promote relaxation and connection. These thoughtfully designed lounges offer clients a refreshing, comfortable environment that feels worlds apart from standard wellness facilities.
    • Real Data Backed By Real Results:
    • Robust Membership Model: Onus’s membership program builds a strong client base with consistent, recurring revenue. Members can also enjoy personalized plans with Longevity Packs, fostering long-term relationships and ensuring retention.

Start franchising with Onus today: https://fransmart.com/brand/onus

Investing in an IV therapy franchise allows you to tap into a thriving wellness market, driven by consumer demand for accessible, effective health solutions. Each of these top franchises offers a unique approach, proven business model, and comprehensive support to help franchisees succeed in a competitive space.

Whether you’re looking for a focused wellness concept like The DripBar or a comprehensive longevity approach like Onus, these franchises provide distinct advantages tailored to different investor goals and customer bases. As the IV therapy industry continues to grow, positioning yourself with a trusted brand can offer both personal and financial rewards. Take the first step in joining a rapidly expanding market and contribute to the future of preventive wellness.

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