The hormone therapy industry is experiencing unprecedented growth, driven by several critical factors:
- An aging population seeking solutions for age-related hormonal changes
- Increased awareness about the impact of hormonal balance on overall health
- Rising healthcare consumerism and personalized medicine trends
- Growing acceptance of hormone optimization as a wellness strategy
Market research indicates that the global hormone therapy market is projected to reach $25.4 billion by 2026, with a compound annual growth rate (CAGR) of 5.6%. This explosive growth presents a golden opportunity for entrepreneurs looking to enter a recession-resistant healthcare market.
Top Hormone Therapy Franchises To Invest In
1. Onus: Combining Lifestyle with Longevity for Health Beyond The Clinic
Short Bio: Onus is a pioneering franchise in the hormone therapy industry, renowned for its innovative, doctor-backed, and client-focused approach to enhancing longevity and overall wellness. By offering personalized, evidence-based treatments—including bioidentical hormone replacement therapy (BHRT), in-location lab testing, NAD+ treatments, IV therapy, and premium supplements—Onus empowers individuals to take proactive control of their health. Their nature-inspired lounges provide a welcoming environment, making longevity-focused care both effective and approachable. They have 6 locations in Denver with franchise opportunities available nationwide.
Onus Franchise Financial Information:
- Franchise Fee: $40,000
- Royalties: 6% of gross revenue
- Initial Investment Range: $230,000 – $515,000
- Minimum Liquid Capital Requirement: $500,000
- Minimum Net Worth: $1M
2. Gameday Men’s Health: Like Sports Clips For Hormone Therapy; Territories Sold Out in US
Short Bio: Gameday Men’s Health is a specialized franchise that addresses male-specific hormonal needs. Focused on testosterone replacement and age management, it caters to men seeking tailored health solutions. As a franchise with the goal to define a new era in men’s health, they are committed to providing fast appointments, immediate results, and a comfortable, discreet environment. They have over 100 units open with 100+ more in development.
Currently, Game Day has sold out of many of their U.S. territories and is focusing on international development. For U.S. based franchisees, this may encourage them to look at other options.
Gameday Franchise Financial Information:
- Franchise Fee: $49,500
- Initial Investment Range: $227,075 to $412,996
- Royalties: 0% of Gross Revenue for the first two months of operation; the greater of 6% of Gross Revenue or the “Minimum Royalty” beginning on the third month of operation and continuing during the remaining years of the initial term
- Brand Development Fee: 2% of Gross Revenue
- Digital Marketing Fee: currently, $2,500 per month
3. Seratonin Wellness Centers: Luxury Anti-aging and Aesthetic Wellness Centers
Short Bio: Aptly named for the hormone that works to stabilize our overall feelings of well-being and happiness, Serotonin — Wellness and Anti-Aging Center — gives its clients a road map for their lifelong wellness journeys, no matter where they may sit on the continuum. They have 100+ locations open or in development across the U.S.
On the more expensive side, Seratonin Wellness Centers initial investment costs reach beyond the $1M mark ($1,363,229) on the high end, starkly above other wellness concepts in the market. Their Net Worth requirement is $2M, narrowing down their pool of potential investors.
Seratonin Franchise Financial Information:
- Franchise Fee: $59,000
- Royalties: 6%/mo
- Brand Fund: 2%/mo
- Initial Investment Range: $665,634 – $1,363,229
- Minimum Liquid Capital Requirement: $500,000
- Minimum Net Worth: $2M
4. Relive Health: New Standard of “Self-Care”
Bio: Relive Health was started in 2017 with the belief they can enhance and extend people’s lives by pairing innovative treatments with unparalleled client care. They have spread out services across wellness, aesthetics, laser treatments, and hormone therapy. They have 17 locations open with 200 in the pipeline, while having served only 6,000+ clients amongst open locations.
Relive Health Franchise Financial Information:
- Franchise Fee: $75k
- Royalties: N/A
- Initial Investment Range: $262k– $669k
- Minimum Liquid Capital Requirement: $250k
- Minimum Net Worth: $750k
5. Regenesis Hrt: Hormone Therapy + Patient Care
Bio: Regenesis HRT franchise focuses on concierge multi-location medical practice groups, specializing in preventative and regenerative hormone replacement therapies. They currently have 4 locations open in Florida and are looking for franchise partners to expand.
Alpha Hormones Franchise Financial Information:
- Franchise Fee: $50,000
- Royalties: 8% of Gross Sale
- Initial Investment Range: $135,000 – $321,000
- Minimum Liquid Capital Requirement: N/A
- Minimum Net Worth: N/A
Our Recommended Choice: Onus
Among the top hormone therapy franchise opportunities, Onus distinguishes itself through its strong brand identity and innovative service model. Unlike competitors such as Seratonin Wellness Centers, which require significantly higher upfront investments, or Gameday Men’s Health, which has sold out of most U.S. territories, Onus offers a balance of affordability, available territories, and a unique lifestyle based approach not found anywhere else in the industry.,
That balance makes Onus the top option for investors seeking a hormone therapy franchise in 2025. Onus is a emerging brand with all the pieces to be the top longevity franchise in the world.
Why More Investors Are Shifting to Medical Franchise Opportunities
Medical franchises, particularly in the wellness and hormone therapy sectors, are gaining traction due to their adaptability, lower startup costs compared to traditional healthcare businesses, and consistent demand regardless of economic conditions. These businesses are designed to be easy to operate, with proven systems, extensive training, and ongoing support for franchisees. For physicians and healthcare professionals, investing in medical franchises offers a natural extension of their expertise while tapping into the booming wellness economy.